Motif ID: HOX{A4,D4}.p2

Z-value: 0.441


Transcription factors associated with HOX{A4,D4}.p2:

Gene SymbolEntrez IDGene Name
HOXA4 3201 homeobox A4
HOXD4 3233 homeobox D4

Activity-expression correlation:

Gene SymbolPromoterPearson corr. coef.P-valuePlot
HOXA4chr7_-_27170351-0.136.2e-01Click!


Activity profile for motif HOX{A4,D4}.p2.

activity profile for motif HOX{A4,D4}.p2


Sorted Z-values histogram for motif HOX{A4,D4}.p2

Sorted Z-values for motif HOX{A4,D4}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HOX{A4,D4}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr7_+_26400503 0.959 NM_001199837
SNX10
sorting nexin 10
chr6_+_12717036 0.916 NM_001242648
NM_030948
PHACTR1

phosphatase and actin regulator 1

chr22_+_22735134 0.865 CYAT1
immunoglobulin lambda light chain-like
chr17_+_18768781 0.718 NM_001243940
PRPSAP2
phosphoribosyl pyrophosphate synthetase-associated protein 2
chr4_-_84035888 0.685 PLAC8
placenta-specific 8
chr6_+_32605182 0.673 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr6_+_6588933 0.626 NM_004271
LY86
lymphocyte antigen 86
chr4_-_84035908 0.620 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr11_+_22688156 0.566 NM_001143830
GAS2
growth arrest-specific 2
chrX_+_37639246 0.561 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr8_-_95449131 0.557 NM_001205263
RAD54B
RAD54 homolog B (S. cerevisiae)
chr1_-_207095198 0.549 NM_001193338
NM_001142473
NM_005449
FAIM3


Fas apoptotic inhibitory molecule 3


chr7_-_150329735 0.540 NM_001244071
NM_001244072
NM_024711
GIMAP6


GTPase, IMAP family member 6


chr17_-_38721701 0.527 NM_001838
CCR7
chemokine (C-C motif) receptor 7
chrX_-_131573638 0.505 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr12_+_54891539 0.483 NCKAP1L
NCK-associated protein 1-like
chrX_+_37639306 0.479 CYBB
cytochrome b-245, beta polypeptide
chr22_+_22735207 0.478 IGLJ3
immunoglobulin lambda joining 3
chr22_+_22758538 0.463


chr14_-_107179043 0.462 IGHA1
immunoglobulin heavy constant alpha 1
chr12_+_54891522 0.457 NCKAP1L
NCK-associated protein 1-like
chr6_-_41703938 0.452 NM_001167827
TFEB
transcription factor EB
chr10_-_116392099 0.441 ABLIM1
actin binding LIM protein 1
chr4_+_74269971 0.434 NM_000477
ALB
albumin
chr6_-_32784727 0.430 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr22_+_22786283 0.428


chr12_+_54891491 0.425 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr12_-_102874299 0.423 IGF1
insulin-like growth factor 1 (somatomedin C)
chr19_-_7766978 0.407 NM_001220500
NM_002002
FCER2

Fc fragment of IgE, low affinity II, receptor for (CD23)

chr3_+_63884074 0.400 NM_001177387
ATXN7
ataxin 7
chr1_-_160617042 0.390 NM_003037
SLAMF1
signaling lymphocytic activation molecule family member 1
chr13_+_43136871 0.386 NM_033012
TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
chr7_+_20655244 0.385 NM_001163941
ABCB5
ATP-binding cassette, sub-family B (MDR/TAP), member 5
chr12_-_102874321 0.378 IGF1
insulin-like growth factor 1 (somatomedin C)
chr12_-_102874373 0.376 NM_000618
NM_001111283
NM_001111285
IGF1


insulin-like growth factor 1 (somatomedin C)


chr3_+_63953419 0.357 NM_001128149
ATXN7
ataxin 7
chr12_+_54892567 0.356 NM_001184976
NCKAP1L
NCK-associated protein 1-like
chr4_+_40198526 0.355 NM_004310
RHOH
ras homolog gene family, member H
chr14_+_64680858 0.352 NM_182913
SYNE2
spectrin repeat containing, nuclear envelope 2
chr17_-_62097937 0.345 NM_001099786
NM_001099787
NM_001099788
NM_001099789
ICAM2



intercellular adhesion molecule 2



chr4_-_153273683 0.345 NM_018315
FBXW7
F-box and WD repeat domain containing 7
chr1_+_167298280 0.343 NM_001198783
POU2F1
POU class 2 homeobox 1
chr7_+_116660263 0.342 ST7
suppression of tumorigenicity 7
chr6_-_26235160 0.340 NM_005320
HIST1H1D
histone cluster 1, H1d
chr10_+_11047253 0.336 NM_001025077
CELF2
CUGBP, Elav-like family member 2
chr13_-_41593405 0.333 ELF1
E74-like factor 1 (ets domain transcription factor)
chrX_-_33357725 0.323 NM_000109
DMD
dystrophin
chr5_-_88119604 0.319 NM_001193348
NM_001193349
MEF2C

myocyte enhancer factor 2C

chr11_+_60223281 0.319 NM_021950
NM_152866
MS4A1

membrane-spanning 4-domains, subfamily A, member 1

chr2_+_33701678 0.318 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr14_-_95608054 0.317 NM_030621
DICER1
dicer 1, ribonuclease type III
chr2_-_158300517 0.316 NM_004288
CYTIP
cytohesin 1 interacting protein
chr6_+_135502445 0.315 NM_001130172
NM_001130173
NM_001161656
NM_001161657
NM_001161658
NM_001161659
NM_001161660
NM_005375
MYB







v-myb myeloblastosis viral oncogene homolog (avian)







chr10_+_28878666 0.315 WAC
WW domain containing adaptor with coiled-coil
chr1_+_167298382 0.312 POU2F1
POU class 2 homeobox 1
chr17_-_62084282 0.306 NM_000873
ICAM2
intercellular adhesion molecule 2
chr14_-_54423448 0.300 NM_001202
NM_130850
BMP4

bone morphogenetic protein 4

chrX_+_1455508 0.299 NM_002183
IL3RA
interleukin 3 receptor, alpha (low affinity)
chrY_+_1405508 0.296 NM_002183
IL3RA
interleukin 3 receptor, alpha (low affinity)
chrX_+_12885190 0.295 NM_016562
TLR7
toll-like receptor 7
chr6_+_32407618 0.291 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr7_+_116660291 0.290 ST7
suppression of tumorigenicity 7
chr1_-_108231122 0.289 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr7_+_73624086 0.284 NM_014146
NM_032463
NM_032464
LAT2


linker for activation of T cells family, member 2


chr4_+_68424444 0.281 NM_012108
STAP1
signal transducing adaptor family member 1
chr1_+_192544856 0.277 NM_002922
RGS1
regulator of G-protein signaling 1
chr14_-_23426356 0.276 HAUS4
HAUS augmin-like complex, subunit 4
chr12_-_102874340 0.275 IGF1
insulin-like growth factor 1 (somatomedin C)
chr14_-_23426265 0.272 NM_001166269
NM_001166270
NM_017815
HAUS4


HAUS augmin-like complex, subunit 4


chr3_-_57234279 0.271 NM_003865
HESX1
HESX homeobox 1
chr1_-_51887740 0.268 NM_001159969
EPS15
epidermal growth factor receptor pathway substrate 15
chr2_+_54683276 0.263 NM_003128
SPTBN1
spectrin, beta, non-erythrocytic 1
chr12_-_102874158 0.262 IGF1
insulin-like growth factor 1 (somatomedin C)
chr4_-_151770611 0.258 LRBA
LPS-responsive vesicle trafficking, beach and anchor containing
chr14_+_58906398 0.257 NM_001244193
KIAA0586
KIAA0586
chr5_+_67586466 0.257 NM_181504
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chrX_-_119445306 0.257 NM_001104544
NM_001104545
NM_017938
FAM70A


family with sequence similarity 70, member A


chr14_-_107099379 0.252 IGHG1
IGHG3
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr7_-_87342569 0.252 NM_000927
ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr1_-_150738292 0.252 NM_001199739
NM_004079
CTSS

cathepsin S

chr3_+_186739643 0.249 NM_003032
ST6GAL1
ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
chr11_+_128563973 0.246 FLI1
Friend leukemia virus integration 1
chr1_-_151414641 0.242 NM_207171
POGZ
pogo transposable element with ZNF domain
chr6_+_64356430 0.242 NM_015153
PHF3
PHD finger protein 3
chr1_+_6105980 0.239 NM_001199862
KCNAB2
potassium voltage-gated channel, shaker-related subfamily, beta member 2
chr2_+_143886898 0.237 NM_018460
ARHGAP15
Rho GTPase activating protein 15
chr20_-_34243118 0.236 RBM12
RNA binding motif protein 12
chr4_-_40517913 0.232 NM_019027
RBM47
RNA binding motif protein 47
chr10_+_11047274 0.232 CELF2
CUGBP, Elav-like family member 2
chr1_+_111415791 0.228 CD53
CD53 molecule
chr13_-_41593491 0.228 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr6_+_100054649 0.224 NM_021620
PRDM13
PR domain containing 13
chr2_-_20527120 0.222 NM_015317
PUM2
pumilio homolog 2 (Drosophila)
chr17_-_64225496 0.222 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr2_+_143886969 0.219 ARHGAP15
Rho GTPase activating protein 15
chrX_-_32173585 0.219 NM_004013
NM_004020
NM_004021
NM_004022
NM_004023
DMD




dystrophin




chr22_+_21128378 0.217 NM_000185
SERPIND1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr16_+_28943259 0.216 NM_001178098
NM_001770
CD19

CD19 molecule

chr2_+_33701320 0.214 NM_001139488
RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr12_-_46633551 0.211 SLC38A1
solute carrier family 38, member 1
chr4_+_89378234 0.209 NM_016323
HERC5
hect domain and RLD 5
chr12_-_53601051 0.209 ITGB7
integrin, beta 7
chr6_-_32812711 0.205 NM_004159
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr1_+_111415721 0.204 NM_000560
CD53
CD53 molecule
chr11_+_128563993 0.204 FLI1
Friend leukemia virus integration 1
chr17_+_25958217 0.203 LGALS9
lectin, galactoside-binding, soluble, 9
chr11_-_67450536 0.202 RPL37
ribosomal protein L37
chr4_+_106631966 0.202 NM_001031720
GSTCD
glutathione S-transferase, C-terminal domain containing
chr1_-_9117554 0.199 SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr22_+_22550112 0.199


chr18_+_32556891 0.199 NM_001143826
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr22_+_22712091 0.198 IGLV1-44
IGL@
immunoglobulin lambda variable 1-44
immunoglobulin lambda locus
chr6_+_87969619 0.197 ZNF292
zinc finger protein 292
chr2_+_172821874 0.196 HAT1
histone acetyltransferase 1
chr20_+_32150139 0.195 NM_001039709
NM_005093
CBFA2T2

core-binding factor, runt domain, alpha subunit 2; translocated to, 2

chr1_-_114414245 0.194 NM_001193431
NM_012411
NM_015967
PTPN22


protein tyrosine phosphatase, non-receptor type 22 (lymphoid)


chr1_+_158801105 0.193 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr1_+_111772332 0.192 NM_001025199
CHI3L2
chitinase 3-like 2
chr1_+_174843523 0.192 NM_001243763
RABGAP1L
RAB GTPase activating protein 1-like
chr17_+_25958245 0.190 LGALS9
lectin, galactoside-binding, soluble, 9
chr3_+_121774208 0.190 NM_001206924
NM_001206925
NM_175862
CD86


CD86 molecule


chr22_-_42336222 0.188 NM_001110215
CENPM
centromere protein M
chr14_+_21249209 0.185 NM_005615
RNASE6
ribonuclease, RNase A family, k6
chr1_-_150738232 0.184 CTSS
cathepsin S
chr14_-_23285011 0.181 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr5_+_156696351 0.179 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr9_-_86584079 0.177 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr4_-_38806410 0.174 NM_003263
TLR1
toll-like receptor 1
chr14_+_70236266 0.174 SRSF5
serine/arginine-rich splicing factor 5
chr10_+_35426709 0.173 NM_183011
NM_183012
CREM

cAMP responsive element modulator

chr6_-_154651214 0.171 NM_001130699
IPCEF1
interaction protein for cytohesin exchange factors 1
chrX_-_135962872 0.171 RBMX
RNA binding motif protein, X-linked
chr14_-_23288912 0.170 NM_001126106
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr9_-_15510899 0.170 NM_001128217
NM_033222
PSIP1

PC4 and SFRS1 interacting protein 1

chr19_+_40194945 0.169 NM_020129
NM_203471
LGALS14

lectin, galactoside-binding, soluble, 14

chr19_-_48744276 0.169 NM_001184900
CARD8
caspase recruitment domain family, member 8
chr10_-_101690655 0.169 DNMBP
dynamin binding protein
chr15_+_100173182 0.168 NM_001130928
MEF2A
myocyte enhancer factor 2A
chr14_-_55650348 0.168 DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr1_-_23886284 0.168 NM_002167
ID3
inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
chrX_-_119445279 0.167 FAM70A
family with sequence similarity 70, member A
chr22_+_37309618 0.165 NM_000395
CSF2RB
colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
chr4_-_76944585 0.164 NM_001565
CXCL10
chemokine (C-X-C motif) ligand 10
chr8_-_28347733 0.163 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr4_+_100495972 0.162 MTTP
microsomal triglyceride transfer protein
chr10_+_97471535 0.162 NM_001098175
ENTPD1
ectonucleoside triphosphate diphosphohydrolase 1
chr2_-_20512016 0.161 PUM2
pumilio homolog 2 (Drosophila)
chr1_-_9129666 0.161 NM_001135585
NM_003039
SLC2A5

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

chr14_-_38064440 0.161 NM_004496
FOXA1
forkhead box A1
chr14_-_38064176 0.160 FOXA1
forkhead box A1
chr2_-_171923482 0.160 NM_001136555
TLK1
tousled-like kinase 1
chr12_+_12938540 0.160 NM_030817
APOLD1
apolipoprotein L domain containing 1
chr1_+_79115476 0.159 NM_006417
IFI44
interferon-induced protein 44
chr14_+_88471467 0.159 NM_003608
GPR65
G protein-coupled receptor 65
chr1_+_39922262 0.159 MACF1
microtubule-actin crosslinking factor 1
chrX_-_53629607 0.158 HUWE1
HECT, UBA and WWE domain containing 1
chr1_+_209941894 0.158 TRAF3IP3
TRAF3 interacting protein 3
chr16_+_31366529 0.158 ITGAX
integrin, alpha X (complement component 3 receptor 4 subunit)
chr7_-_1595746 0.157 NM_001097620
TMEM184A
transmembrane protein 184A
chrX_-_135962929 0.157 NM_001164803
NM_002139
RBMX

RNA binding motif protein, X-linked

chr12_+_54447660 0.157 NM_153633
HOXC4
HOXC6
homeobox C4
homeobox C6
chr1_-_27952591 0.156 NM_001042747
FGR
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
chr12_-_53600999 0.156 NM_000889
ITGB7
integrin, beta 7
chr17_+_41158741 0.155 NM_005533
IFI35
interferon-induced protein 35
chr5_-_94224601 0.155 MCTP1
multiple C2 domains, transmembrane 1
chr1_+_244216506 0.154 NM_006352
ZNF238
zinc finger protein 238
chr3_-_47933997 0.154 MAP4
microtubule-associated protein 4
chr13_-_75901897 0.153 TBC1D4
TBC1 domain family, member 4
chr5_+_180467224 0.152 NM_152547
BTNL9
butyrophilin-like 9
chr17_+_67498391 0.151 MAP2K6
mitogen-activated protein kinase kinase 6
chr5_+_49962771 0.150 NM_001178056
NM_024615
PARP8

poly (ADP-ribose) polymerase family, member 8

chr14_-_106641585 0.147 IGHV4-31
IGHA1
IGHA2
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant alpha 2 (A2m marker)
immunoglobulin heavy constant gamma 1 (G1m marker)
chr14_-_106539099 0.147 IGHA1
IGHG1
IGHG3
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant gamma 3 (G3m marker)
chr9_+_79968344 0.146 VPS13A
vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr6_-_133078894 0.145 NM_001242350
NM_004665
VNN2

vanin 2

chr11_-_47545539 0.144 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr22_+_22735202 0.144


chr2_+_79740171 0.144 CTNNA2
catenin (cadherin-associated protein), alpha 2
chr8_+_11351509 0.144 NM_001715
BLK
B lymphoid tyrosine kinase
chr4_+_74270832 0.143 ALB
albumin
chrX_+_99839789 0.143 NM_022144
TNMD
tenomodulin
chr1_+_66797775 0.142 NM_001037339
PDE4B
phosphodiesterase 4B, cAMP-specific
chr11_+_36616039 0.142 NM_138787
C11orf74
chromosome 11 open reading frame 74
chr16_+_10522724 0.141 NM_024997
ATF7IP2
activating transcription factor 7 interacting protein 2
chrX_-_124097601 0.141 NM_001163278
NM_001163279
NM_014253
ODZ1


odz, odd Oz/ten-m homolog 1 (Drosophila)


chr17_-_48785016 0.140 NM_052855
ANKRD40
ankyrin repeat domain 40
chr5_+_69696805 0.138 SMA4
glucuronidase, beta pseudogene
chr4_-_153303663 0.138 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr6_-_22303014 0.137 NM_001163558
PRL
prolactin
chr11_-_118900078 0.137 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr2_+_102979096 0.136 NM_003855
IL18R1
interleukin 18 receptor 1
chr15_+_86220267 0.134 NM_144767
AKAP13
A kinase (PRKA) anchor protein 13
chr22_+_22676814 0.133


chr19_+_45409003 0.133 NM_000041
APOE
apolipoprotein E
chr2_+_38893051 0.132 NM_138801
GALM
galactose mutarotase (aldose 1-epimerase)
chr20_-_45976626 0.132 ZMYND8
zinc finger, MYND-type containing 8
chr17_+_25958257 0.131 LGALS9
lectin, galactoside-binding, soluble, 9
chr4_-_186577858 0.130 SORBS2
sorbin and SH3 domain containing 2
chr13_+_33160630 0.130 PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr1_+_10490158 0.129 NM_198544
NM_199006
NM_199294
APITD1-CORT

APITD1
APITD1-CORT readthrough

apoptosis-inducing, TAF9-like domain 1

Gene Ontology Analysis

Nothing significant found in process category.

Nothing significant found in compartment category.

Nothing significant found in function category.